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De Wit, Harriet
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overview The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
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Concept Aged, 80 and over
Concept Adolescent
Concept Aged
Concept Adult
Concept Animals
Concept Animals, Laboratory
Concept Central Nervous System Stimulants
Concept Association Learning
Concept Cannabis
Concept Central Nervous System Depressants
Concept gamma-Aminobutyric Acid
Concept Computers
Concept Demography
Concept Homozygote
Concept Discrimination Learning
Concept Hypothalamo-Hypophyseal System
Concept Macaca fascicularis
Concept Counseling
Concept Frontal Lobe
Concept Neurosecretory Systems
Concept Terminology as Topic
Concept Half-Life
Concept Insulin Infusion Systems
Concept Feedback
Concept Language
Concept Lysergic Acid Diethylamide
Concept Functional Laterality
Concept Lipids
Concept Luteal Phase
Concept Mice, Inbred C57BL
Concept Middle Aged
Concept Outpatients
Concept Parasympathetic Nervous System
Concept Parietal Lobe
Concept Pattern Recognition, Automated
Concept Psychiatry
Concept Image Processing, Computer-Assisted
Concept Writing
Concept Sympathetic Nervous System
Concept Humans
Concept Linear Models
Concept Students
Concept Verbal Learning
Concept Substance-Related Disorders
Concept Models, Animal
Concept Mice, Inbred DBA
Concept Rats, Sprague-Dawley
Concept Rats, Wistar
Concept Serotonin Plasma Membrane Transport Proteins
Concept Plant Structures
Concept Amino Acid Substitution
Concept Leptin
Concept Databases, Genetic
Concept Periodicals as Topic
Concept Mice
Concept Psychology
Concept Research Design
Concept Cell Phone
Concept Socioeconomic Factors
Concept Temporal Lobe
Concept Norepinephrine Plasma Membrane Transport Proteins
Concept Rats
Concept Logistic Models
Concept Child of Impaired Parents
Concept Quinolinic Acid
Concept Linkage Disequilibrium
Concept Central Nervous System Sensitization
Concept Arachidonic Acids
Concept Artificial Intelligence
Concept Communication
Concept Heterozygote
Concept Learning
Concept Luteinizing Hormone
Concept Longitudinal Studies
Concept Pituitary-Adrenal System
Concept Semantics
Concept Speech
Concept Databases, Factual
Concept Membrane Transport Proteins
Concept Dopamine Plasma Membrane Transport Proteins
Concept Drug Users
Concept Young Adult
Academic Article Self-administration of pentobarbital in light and moderate alcohol drinkers.
Academic Article Effects of d-amphetamine in grouped versus isolated humans.
Academic Article Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers.
Academic Article Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment.
Academic Article The effects of ethanol on the relative preference for cigarettes.
Academic Article Interaction of expectancy and the pharmacological effects of d-amphetamine: subjective effects and self-administration.
Academic Article Effects of triazolam at three phases of the menstrual cycle.
Academic Article Acute effects of estradiol pretreatment on the response to d-amphetamine in women.
Academic Article Laboratory-based assessment of alcohol craving in social drinkers.
Academic Article Testing the abuse liability of anxiolytic and hypnotic drugs in humans.
Academic Article Acute effects of d-amphetamine during the follicular and luteal phases of the menstrual cycle in women.
Academic Article Lack of effects of acute estradiol on mood in postmenopausal women.
Academic Article An fMRI study of the effect of amphetamine on brain activity.
Academic Article Subjective and objective responses to ethanol in moderate/heavy and light social drinkers.
Academic Article Acute effects of d-amphetamine during the early and late follicular phases of the menstrual cycle in women.
Academic Article Acute doses of d-amphetamine and bupropion increase cigarette smoking.
Academic Article Preference procedures for testing the abuse liability of drugs in humans.
Academic Article Individual differences in responses to ethanol and d-amphetamine: a within-subject study.
Academic Article Effects of THC on behavioral measures of impulsivity in humans.
Academic Article GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings.
Academic Article Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.
Academic Article Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase.
Academic Article Effects of stress on responses to methamphetamine in humans.
Academic Article Dopamine transporter gene associated with diminished subjective response to amphetamine.
Academic Article Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine.
Academic Article Menstrual cycle phase and responses to drugs of abuse in humans.
Academic Article Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement.
Academic Article Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one-like immunoreactivity in healthy men and women.
Academic Article Personality and the subjective effects of acute amphetamine in healthy volunteers.
Academic Article Subjective effects of slow-release bupropion versus caffeine as determined in a quasi-naturalistic setting.
Academic Article Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users.
Academic Article Norepinephrine transporter gene variation modulates acute response to D-amphetamine.
Academic Article The alcohol clamp: applications, challenges, and new directions--an RSA 2004 symposium summary.
Academic Article Biological and behavioral markers of alcohol sensitivity.
Academic Article Does stress reactivity or response to amphetamine predict smoking progression in young adults? A preliminary study.
Academic Article Personality and gender differences in effects of d-amphetamine on risk taking.
Academic Article Sleep deprivation increases cigarette smoking.
Academic Article Further evidence of association between amphetamine response and SLC6A2 gene variants.
Academic Article The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers.
Academic Article Effects of MDMA on sociability and neural response to social threat and social reward.
Academic Article Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans.
Academic Article Effects of acute progesterone administration upon responses to acute psychosocial stress in men.
Academic Article More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine.
Academic Article Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.
Academic Article Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers.
Academic Article Incubation of cue-induced cigarette craving during abstinence in human smokers.
Academic Article More on ADORA.
Academic Article Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence.
Academic Article Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers.
Academic Article Test-retest characteristics of the Balloon Analogue Risk Task (BART).
Academic Article Quantifying talk: developing reliable measures of verbal productivity.
Academic Article Psychoactive drugs and false memory: comparison of dextroamphetamine and d-9-tetrahydrocannabinol on false recognition.
Academic Article Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men.
Academic Article Translational genetic approaches to substance use disorders: bridging the gap between mice and humans.
Academic Article Reduced subjective response to acute ethanol administration among young men with a broad bipolar phenotype.
Academic Article Balanced placebo design with marijuana: pharmacological and expectancy effects on impulsivity and risk taking.
Academic Article Caffeine increases psychomotor performance on the effort expenditure for rewards task.
Academic Article Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images.
Academic Article Effects of nicotine on attention and inhibitory control in healthy nonsmokers.
Academic Article Hormonal, cardiovascular, and subjective responses to acute stress in smokers.
Academic Article Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.
Academic Article Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase.
Academic Article Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers.
Academic Article Amping up effort: effects of d-amphetamine on human effort-based decision-making.
Academic Article Evaluation of the abuse potential of pagoclone, a partial GABAA agonist.
Academic Article Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements.
Academic Article Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans.
Academic Article Stress-induced changes in mood and cortisol release predict mood effects of amphetamine.
Academic Article Effect of social stress during acute nicotine abstinence.
Academic Article Effect of d-amphetamine on post-error slowing in healthy volunteers.
Academic Article Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
Academic Article Acute tolerance to subjective but not cardiovascular effects of d-amphetamine in normal, healthy men.
Academic Article Preference for ethanol and diazepam in light and moderate social drinkers: a within-subjects study.
Academic Article Individual differences in the priming effect of ethanol in social drinkers.
Academic Article Acute hydrocortisone administration does not affect subjective responses to d-amphetamine in humans.
Academic Article Lack of effect of intravenous hydrocortisone on mood in humans: a preliminary study.
Academic Article Biphasic alcohol response differs in heavy versus light drinkers.
Academic Article The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers.
Academic Article Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants.
Academic Article Serotonin transporter genotype and acute subjective response to amphetamine.
Academic Article Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.
Academic Article Bupropion improves attention but does not affect impulsive behavior in healthy young adults.
Academic Article Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine.
Academic Article Sex hormones: a new treatment for cocaine abuse?
Academic Article Effects of amphetamine on reactivity to emotional stimuli.
Academic Article Lack of association between COMT and working memory in a population-based cohort of healthy young adults.
Academic Article Relationship of self-reported and acute stress to smoking in emerging adult smokers.
Academic Article Conditioned preference to a methamphetamine-associated contextual cue in humans.
Academic Article Psychopharmacology of theobromine in healthy volunteers.
Academic Article The drug effects questionnaire: psychometric support across three drug types.
Academic Article The combined effects of alcohol, caffeine, and expectancies on subjective experience, impulsivity, and risk-taking.
Academic Article Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans.
Academic Article Personality and the acute subjective effects of d-amphetamine in humans.
Academic Article Does COMT genotype influence the effects of d-amphetamine on executive functioning?
Academic Article Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol.
Academic Article In the company of others: social factors alter acute alcohol effects.
Academic Article Personality traits modulate emotional and physiological responses to stress.
Academic Article Inattention, impulsive action, and subjective response to D-amphetamine.
Academic Article Opioid modulation of resting-state anterior cingulate cortex functional connectivity.
Academic Article Contextual conditioning enhances the psychostimulant and incentive properties of d-amphetamine in humans.
Academic Article Genetic factors modulating the response to stimulant drugs in humans.
Academic Article Using conditioned place preference to identify relapse prevention medications.
Academic Article MDMA: a social drug in a social context.
Academic Article Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans.
Academic Article Cannabinoid modulation of amygdala subregion functional connectivity to social signals of threat.
Academic Article Acquisition of responses to a methamphetamine-associated cue in healthy humans: self-report, behavioral, and psychophysiological measures.
Academic Article Sex differences in impulsive action and impulsive choice.
Academic Article Amphetamine increases errors during episodic memory retrieval.
Academic Article Effects of acute doses of prosocial drugs methamphetamine and alcohol on plasma oxytocin levels.
Academic Article Amphetamine fails to alter cued recollection of emotional images: study of encoding, retrieval, and state-dependency.
Academic Article Farewell to Drs. Ivan Diamond and T.-K. Li.
Academic Article MDMA alters emotional processing and facilitates positive social interaction.
Academic Article 'Ecstasy' as a social drug: MDMA preferentially affects responses to emotional stimuli with social content.
Academic Article A window into the intoxicated mind? Speech as an index of psychoactive drug effects.
Academic Article Sweet taste liking is associated with impulsive behaviors in humans.
Academic Article Effects of acute methamphetamine on emotional memory formation in humans: encoding vs consolidation.
Academic Article Test-retest reliability of behavioral measures of impulsive choice, impulsive action, and inattention.
Academic Article Effects of MDMA and Intranasal oxytocin on social and emotional processing.
Academic Article Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans.
Academic Article MDMA effects consistent across laboratories.
Academic Article Effects of oxycodone on brain responses to emotional images.
Academic Article Intimate insight: MDMA changes how people talk about significant others.
Academic Article Prosocial effects of MDMA: A measure of generosity.
Academic Article The Ups and Downs of 3,4-Methylenedioxymethamphetamine: Linking Subjective Effects to Spontaneous Brain Function.
Academic Article A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial.
Academic Article Effects of buprenorphine on responses to social stimuli in healthy adults.
Academic Article Interrelationships among parental family history of substance misuse, delay discounting, and personal substance use.
Academic Article Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers.
Academic Article Acute Effects of Alcohol on Encoding and Consolidation of Memory for Emotional Stimuli.
Academic Article Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology.
Academic Article Acquisition of Conditioned Responses to a Novel Alcohol-Paired Cue in Social Drinkers.
Academic Article Effects of d-amphetamine upon psychosocial stress responses.
Academic Article Extinction of Conditioned Responses to Methamphetamine-Associated Stimuli in Healthy Humans.
Academic Article The latent structure of impulsivity: impulsive choice, impulsive action, and impulsive personality traits.
Academic Article Insulin administered by needle-free jet injection corrects marked hyperglycaemia faster in overweight or obese patients with diabetes.
Academic Article Oxytocin receptor gene variation predicts subjective responses to MDMA.
Academic Article Naltrexone alters the processing of social and emotional stimuli in healthy adults.
Academic Article Lost in Translation: CRF1 Receptor Antagonists and Addiction Treatment.
Academic Article Alcohol-induced place conditioning in moderate social drinkers.
Academic Article Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers: a pilot study.
Academic Article Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration.
Academic Article Virtual reality conditioned place preference using monetary reward.
Academic Article The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?
Academic Article Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity.
Academic Article MDMA does not alter responses to the Trier Social Stress Test in humans.
Academic Article Special issue: recognizing the lifetime scientific contributions of Athina Markou.
Academic Article Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene-based tests, genome-wide variation, and SNP heritability.
Academic Article Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress.
Award or Honor Receipt Marian W. Fischman Memorial Lectureship Award
Award or Honor Receipt Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
Grant Determinants of Drug Preference in Humans
Academic Article Neural activation to monetary reward is associated with amphetamine reward sensitivity.
Academic Article Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.
Academic Article Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry.
Academic Article Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.
Academic Article Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers.
Academic Article Considering the context: social factors in responses to drugs in humans.
Academic Article Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.
Academic Article Sweet taste liking is associated with subjective response to amphetamine in women but not men.
Academic Article Does human language limit translatability of clinical and preclinical addiction research?
Academic Article MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections.
Academic Article ?9-Tetrahydrocannabinol at Retrieval Drives False Recollection of Neutral and Emotional Memories.
Academic Article Effects of Buprenorphine on Responses to Emotional Stimuli in Individuals with a Range of Mood Symptomatology.
Academic Article Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans.
Academic Article Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers.
Academic Article Intranasal Oxytocin Does Not Modulate Responses to Alcohol in Social Drinkers.
Academic Article Neural responses to cues paired with methamphetamine in healthy volunteers.
Academic Article GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
Academic Article Effects of methamphetamine on neural responses to visual stimuli.
Academic Article Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes.
Academic Article Neural correlates of inhibition and reward are negatively associated.
Academic Article Multidimensional latent structure of risk-related phenotypes in healthy young adults.
Academic Article Effects of MDMA on attention to positive social cues and pleasantness of affective touch.
Academic Article Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults.
Academic Article Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability.
Academic Article Subjective responses to amphetamine in young adults with previous mood elevation experiences.
Academic Article Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers.
Academic Article Developing a phone-based measure of impairment after acute oral ?9-tetrahydrocannabinol.
Academic Article ?9-Tetrahydrocannabinol During Encoding Impairs Perceptual Details yet Spares Context Effects on Episodic Memory.
Academic Article Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.
Academic Article Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.
Academic Article Poor inhibitory control is associated with greater stimulation and less sedation following alcohol.
Academic Article Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.
Academic Article Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Academic Article Stability of acute responses to drugs in humans across repeated testing: Findings with alcohol and amphetamine.
Academic Article Striatal activation to monetary reward is associated with alcohol reward sensitivity.
Award or Honor Receipt Lifetime Achievement Award
Award or Honor Receipt John F. Lemieux Medal for Distinguished Alumni
Academic Article Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.
Academic Article Neural activation during anticipation of monetary gain or loss does not associate with positive subjective response to alcohol in binge drinkers.
Academic Article Acute effects of alcohol on resting-state functional connectivity in healthy young men.
Academic Article Subjective responses predict d-amphetamine choice in healthy volunteers.
Academic Article Challenges in translational research: MDMA in the laboratory versus therapeutic settings.
Academic Article Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.
Academic Article The influence of conditioned stimuli on [11C]-(+)-PHNO PET binding in tobacco smokers after a one week abstinence.
Academic Article Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults.
Academic Article Acute effects of oral delta-9-tetrahydrocannabinol (THC) on autonomic cardiac activity and their relation to subjective and anxiogenic effects.
Academic Article Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women.
Academic Article Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
Academic Article Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.
Concept Virtual Reality
Concept Healthy Volunteers
Grant Craving During Smoking Abstinence: Does it Abate or Incubate?
Grant DRUGS OF ABUSE ON REGIONAL CEREBRAL METABOLISM AND MOOD
Grant Memory effects of stimulant drugs in humans
Grant Nicotinic Involvement &Consumption of Alcohol in Humans
Grant BLOCKADE OF METHAMPHETAMINE SUBJECTIVE EFFECTS IN HUMANS
Grant Drug Abuse and Impulsivity: Human Laboratory Models
Grant Is Ecstasy an Empathogen? Effects of MDMA on Social and Emotional Processing
Grant PHARMACOLOGIC STUDIES OF MARIJUANA &ALPHA THC IN HUMAN
Grant Inhibitory Control and Drug Reward in Humans
Grant The genetic basis of impulsive behavior in humans
Grant BEHAVIORAL ECONOMICS OF DRUG CHOICE
Academic Article The acute effects of psychoactive drugs on emotional episodic memory encoding, consolidation, and retrieval: A comprehensive review.
Academic Article Impaired inhibition after delta-9-tetrahydrocannabinol in women not related to circulating estradiol levels.
Academic Article Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men.
Academic Article Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task.
Academic Article Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults.
Academic Article Greater subjective effects of a low dose of LSD in participants with depressed mood.
Academic Article Lack of effect of methamphetamine on reward-related brain activity in healthy adults.
Academic Article Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.
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